SHOW / EPISODE

GLP-1 Side Effects Aren't Inevitable: How to Avoid Them (with Dr. Matthea Rentea)

57m | Dec 30, 2025

What if I told you that the side effects of nausea, constipation, muscle loss AND burnout on GLP-1s are not inevitable? That in many cases, they're simply a sign the medication is being used the wrong way?

In this week's episode of The Holistic GLP-1 Podcast, I sit down with Dr. Matthea Rentea—a double board-certified obesity medicine physician who is quietly revolutionizing how GLP-1s are used in clinical practice. This is one of the most nuanced, compassionate and empowering conversations we've had about how using GLP-1 medications can be part of a true healing journey—not a crash-and-burn weight loss strategy.


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 SHOW NOTES

 [ 00:00 ] Introduction

 [ 01:20 ] How GLP-1s Changed Obesity Medicine

 [ 05:05 ] Why Dr. Rentea Practices Holistic Medicine

 [ 06:45 ] Dosing Strategy: Why The "Lowest Effective Dose" Works Best

 [ 10:00 ] Carbohydrates, Insulin Resistance & Food Ordering

 [ 13:40 ] How to Identify Insulin Resistance Early

 [ 16:50 ] Why Side Effects Are Often Preventable

 [ 18:40 ] Protein, Fiber & Protecting Muscle and Longevity

 [ 22:20 ] Lean Mass vs. Skeletal Muscle Mass

 [ 25:20 ] Bone Health, Strength Training & Aging

 [ 28:30 ] Mindset, Identity & Behavior Change

 [ 33:10 ] Dr. Rentea's Personal Weight Journey

 [ 36:20 ] Are GLP-1s Lifelong?

 [ 41:00 ] Can You "Re-sensitize" to GLP-1s?

 [ 45:10 ] Genetics, Satiety Signaling & Healing Shame

 [ 50:30 ] Supplements on a GLP-1 Journey

 [ 54:50 ] What Real Success Looks Like on GLP-1s

 

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 🔗 Mentioned in This Episode:


 CLICK HERE TO GET ⇒ Free Masterclass: Freedom From Food Noise: https://go.elizabethmcgann.com/start

 

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 Get Connected with Elizabeth McGann:

 Instagram: http://www.instagram.com/elizabethmcgann

 Facebook: https://www.facebook.com/ElizabethMcGannWellness

 LinkedIn: https://www.linkedin.com/in/elizabethmcgann

 X/Twitter: https://twitter.com/ElizabethMcGann

 

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 Learn more about Dr. Matthea Rentea:

 Website: https://www.renteaclinic.com/

 Instagram: https://www.instagram.com/matthearenteamd/?hl=en

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The Holistic GLP-1 Podcast with Elizabeth McGann
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