#213 Hypertension First-Line Medications Troubleshooting | Bread & Butter Series

Why can lower-dose combinations be more effective and better tolerated than maximizing one medication? How to troubleshoot common challenges such as amlodipine edema, gout, electrolyte abnormalities, and the patient who says they cannot tolerate anything? Why ACT (ARBs, Calcium Channel Blockers, Thiazides) is the preferred first-line framework, and how to personalize medication choices based on comorbidities and side effects.

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🔹Transcript and Shownotes

03:00 | Diagnosing Hypertension 

04:10 | When to Start Combination Therapy Instead of Monotherapy 

07:00 | Choosing First-Line Therapy Using the ACT Framework 

13:23 | Why ARBs Are Often Preferred Over ACE Inhibitors 

16:02 | Choosing the Right ARB: Candesartan vs Losartan 

18:39 | Comparing Potency & Duration Across First-Line Antihypertensives 

20:54 | Amlodipine Edema: Why It Happens and How to Fix It 

23:54 | Thiazides: Practical Tips, Electrolyte Problems & Class-Killer Side Effects 

29:33 | Managing Patients Who 'Can't Tolerate' Blood Pressure Medications 

Tags: Hypertension Management, High Blood Pressure, Primary Care, Internal Medicine, Core IM

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